Gastroenterology & Hepatology

Biography

Biography: Vedat Goral

Abstract

Multiple myeloma (MM) is a malignant proliferation of plasma cells that secrete monoclonal immunglobin (M protein). It accounts for 1% of all cancers and 10% of hematological malignancies. Mean age at diagnosis is 66 years. The most common findings are bone pain, pathological fractures, anemia, bone marrow failure, Infections triggered by neutropenia and immunodeficiency, and kidney failure and rarely can cause acute hypercalcaemia, symptomatic hyperviscosity, neuropathy, amyloidosis and coagulopathy.Amyloidosis is a rare disease characterized by nonspecific symptoms and signs. It can be seen anywhere in the gastrointestinal tract.A 76-year-old female patient with multiple myeloma was directed to gastroenterology with rectal bleeding while hospitalized with acute renal failure and hypercalcemia. The patient underwent colonoscopy. and lumen-narrowing, vegetan, erosional, moderately hard, pseudotumor-like, muco-pleural lesions were detected at approximately between 50-60. cm on colonoscopy. There was partial narrowing and pseudotumor in the colon. Six different biopsies were taken from different places on lesions. Homogenous, amorphous material accumulation in the submucosa and around the veins were detected in the biopsy specimens stained with hematoxylin and eosin dye and Congo red. The patient underwent a second colonoscopy 1 month later for control. The lesions detected in the first colonoscopy were not found. On the second colonoscopy, biopsy was taken again from the rectosigmoid region, but it has been observed that the amyloidosis continues in biopsy.In this case, a colonoscopy was performed on the patient who was directed to gastroenterology clinic with rectal bleeding and amyloidosis was detected in the biopsy from tumoral lesions seen in the colonoscopy.