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Kaibullayeva

University of Kazakhstan

Title: Crosssectional study using real world data on the active detection of patients with Inflammatory Bowel Disease in Kazakhstan

Biography

Biography: Kaibullayeva

Abstract

Currently there is no registry of patients with Inflammatory Bowel Disease (IBD) in Kazakhstan. According to official statistics for the year 2017, the prevalence of Crohn's Disease (CD) was 7.4 per 105 and that of Ulcerative Colitis (UC) was 36.7 per 105, with total IBD prevalence 44.1 per 105.

The purpose of this study was to actively identify the prevalence of IBD among the adult population of Kazakhstan.

Methods

This study undertook active identification of cases of IBD among the adult population of Kazakhstan using the 8­item CalproQuest questionnaire (Hasler S et al). If positive IBD symptoms were elicited by the questionnaire, the respondent underwent fecal calprotectin (FC) testing by a semi­quantitative method. If FC was elevated, further clinical assessment was carried out by an IBD specialist.

Results

A total of 115,556 questionnaires were distributed (response rates was 86.5%, mean age 44.2±15.1 years), of which 1,084 (1.08%) reported symptoms concerning for IBD. Of these, 181 of them had a positive express analysis of FC, and 128 of 181 were confirmed to have IBD (36 CD and 92 UC). Among the original sample, the prevalence of IBD was 127.3 per 105 (95% CI: 104.8­149.7 per 105), including CD 35.8 per 105 and UC 91.5 per 105. The prevalence of CD was 24.9 per 105 among males vs. females 42.0 per 105 and for UC 124.3 and 73.0 per 105, respectively.

Conclusions

This estimate of the prevalence of IBD in Kazakhstan exceeds previous estimates by 2.5 times.