14^th Annual Congress on Gastroenterology & Hepatology March 30-31, 2019 Hong Kong, China

Biography:

Dr. Md. Saiful Islam has completed his MBBS from Sir Salimullah Medical College and then joined at Bangabandhu sheikh Mujib Medical University as a Research Assisstant. He completed his postgraduation on Hepatology last year. Already he has published 03 article in different reputed journal and also present his papers in INASL conference. He has a vast experience in gastroenterology and Hepatology and also great interest in the field of research.

Abstract:

Insulin resistance is considered as the major contributor for the development of NAFLD, but it is evident that genetic polymorphism also contribute for the development of necroinflammation and subsequent progression of disease. This study was aimed to compare the effect of insulin resistance and genetic polymorphism on the development of nonalcoholic fatty liver disease.

Materials and methods:

Forty-seven subjects with NAFLD and thirty four controls were selected for the study after ultrasonography of eighty one consecutive apparently healthy subjects. Anthropometric profile [body mass index (BMI), waist circumference (WC) etc,], lipid profile, hepatic aminotransferases, fasting blood glucose (FBG), were recorded and value of homeostasis model assessment of insulin resistance (HOMA-IR) was analysed. PNPLA3 genotyping was also done. To see the association between insulin resistance, and genetic polymorphism with NAFLD was evaluated by multivariate logistic regression analysis after adjusting for potential confounding variables. Risk analysis was performed by calculating the odds ratio (OR) and the 95% confidence interval (CI)

Biography:

Mohamed  has completed his Medical degree  at the age of 25 years from alexandria school of medicine ,Egypt ,he has finished his masters at the age of 28 ,he became a member of the Royal college of physicians at the age of 31 (MRCPUK),he is currently working as an assistant lecturere in the field of gastroenterology and endoscopy and can practice upper and lower endoscopy , he has published a case in the UEG 2018

Abstract:

Distal common bile duct strictures (CBD)are caused by heterogenous group of conditions which can be benign or malignant that  can be managed by different methods .the aim of this study is to compare the role of ERCP versus percutaneous transhepatic approach in the management of distal CBD strictures

Methods: The study was conducted on 40subjects (20 patients with distal CBD strictures with endoscopic management(group I  )and 20 patients with distal CBD strictures with transhepatic management(groupII ).distal CBD strictures will be evaluated by history ,clinical examination,laboratory investiagations ,radiological investigations including (ultrasonography ,multislice CT , MRCP).evaluated outcomes included technical success rate and therapeutic success rate ,major complications rate ,30 –day mortality rates and mean hospital stay.

Results: in our study it was found that 25% of group I was technically unsuccessful while 75% was successful. on the other hand 30% of group II was unsuccessful while 70% was successful it was  also  found that 75% of group I was therapeutically successful while 25% of group I was therapeutically unsuccessful ,on the other hand it was found that 70% of group II was therapeutically successful while 30 % of group II was therapeutically unsuccessful.considering the rate of complications it was found that 30% of group I had developed major complications while 30% of group II had developed major complaications  As regard 30 day mortality It was found that mortality was higher in patients of group II (60%) as compared to group I (40%) however the relation was not statistically significant.The relation between the two groups showed statistical significance as regard mean hospital stay (p=0.0327) , it was showed that the mean hospital stay in group I was (7.35+_5.8) as compared to the mean hospital stay in group II which was (13.5+_10.8)

Conclusions: Distal CBD strictures are better managed by ERCP although they are technically complementary to each other  as compared to transhepatic approach as it provides more diagnostic benefits, less mortality and significant less hospital stay

Biography:

Dr. Miguel Lorenzo Faustino completed his undergraduate degree in Molecular Biology and Biotechnology from the the National Institute of Molecular Biology and Biotechnology in the University of the Philippines. He obtained his medical degree from the University of the Philippines College of Medicine. He is currently completing his Internal Medicine residency training program from the World Citi Medical Center in Quezon City, the Philippines.
 

Abstract:

Gastric cancer is rare before the age 40. Establishing a diagnosis in this subset of younger patients is challenging because initial symptoms are nonspecific. This case report aims to present a case of diffuse gastric adenocarcinoma in a young patient with the intent of raising awareness on its subtle presentation whose clinical diagnosis is anchored on an astute physician’s high index of suspicion. We report the case of a 35 year old, Filipino male, with no known comorbidities and no family history of malignancy, who complained of early satiety and bothersome postprandial fullness 7 months in evolution. Repeated endoscopic evaluation and CT imaging revealed linitis plastica with a rigid and thickened gastric mucosa. Multiple biopsies taken only showed increased lymphoplasmacytic infiltrates with no evidence of dysplasia, metaplasia or atrophy.  In this experience, subtle presentation, inconclusive results of the diagnostic investigation, and the aggressive biology of the disease underscores the importance of the physician’s high index of suspicion in diagnosing gastric cancer in this subset of patients. Establishing a diagnosis early is crucial so that key interventions may be offered and prolong our patient’s life.

Biography:

J.Kaibullayeva has completed PhD at the age of  34 years from Research Institute of cardiology and internal diseases. She is the lecturee, assistant professor of Gastroenterology and Hepatology Department, consultant in National IBD Center (Research Inst of cardiology and internal diseases), Head of Kazakh Founadtion in intestinal study. She has published more than 20 papers in regional and intenational journals, 4 posters in inetrnational confereces, author of National Guidelines in IBD, functional gastrointestinal disoders and cholestatic liver diseases

Abstract:

Currently there is no registry of patients with Inflammatory Bowel Disease (IBD) in Kazakhstan. According to official statistics for the year 2017, the prevalence of Crohn's Disease (CD) was 7.4 per 10⁵ and that of Ulcerative Colitis (UC) was 36.7 per 10⁵, with total IBD prevalence 44.1 per 10⁵.

The purpose of this study was to actively identify the prevalence of IBD among the adult population of Kazakhstan.

Methods

This study undertook active identification of cases of IBD among the adult population of Kazakhstan using the 8­item CalproQuest questionnaire (Hasler S et al). If positive IBD symptoms were elicited by the questionnaire, the respondent underwent fecal calprotectin (FC) testing by a semi­quantitative method. If FC was elevated, further clinical assessment was carried out by an IBD specialist.

Results

A total of 115,556 questionnaires were distributed (response rates was 86.5%, mean age 44.2±15.1 years), of which 1,084 (1.08%) reported symptoms concerning for IBD. Of these, 181 of them had a positive express analysis of FC, and 128 of 181 were confirmed to have IBD (36 CD and 92 UC). Among the original sample, the prevalence of IBD was 127.3 per 10⁵ (95% CI: 104.8­149.7 per 10⁵), including CD 35.8 per 10⁵ and UC 91.5 per 10⁵. The prevalence of CD was 24.9 per 10⁵ among males vs. females 42.0 per 10⁵ and for UC 124.3 and 73.0 per 10⁵, respectively.

Conclusions

This estimate of the prevalence of IBD in Kazakhstan exceeds previous estimates by 2.5 times.